In placebo-controlled studies, the most common events were dry mouth, anorexia, insomnia, constipation … The patient made a full recovery. Subj: menstral side effects, Meridia Date: 4/18/2003 I started taking Meridia 10mg 6 days ago. Meridia(Sibutramine Hydrochloride Monohydrate) side effects drug center, Medical Editor: John P. Cunha, DO, FACOEP. drug development of tolerance, incrementation of doses, drug seeking behavior). In these studies, potentially clinically significant values (total bilirubin Sibutramine, formerly sold under the brand name Meridia among others, is an appetite suppressant which has been discontinued in many countries. Find patient medical information for Meridia Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. You may report side effects to FDA at 1-800-FDA-1088. ulcer, tongue edema. patient receiving sibutramine during premarketing studies. Meridia should not be taken with any other drugs that have an effect on the serotonin level. who received sibutramine in controlled and uncontrolled premarketing studies. In general, sibutramine is well-tolerated. Tell your doctor if you have any side effect that bothers you or that does not go away. [Ref], Genitourinary side effects have included dysmenorrhea (3.5%), urinary tract infection (2.3%), vaginal monilia (1.2%), metrorrhagia (1.0%), and urinary retention. [Ref], Respiratory system side effects have included rhinitis (10.2%), pharyngitis (10.0%), sinusitis (5.0%), increased cough (3.8%), and laryngitis (1.3%). of the medication, dialysis and oral corticosteroids were administered; renal A few cases of QT interval prolongation have also been reported. Less than 0.1% of patients have experienced seizures during therapy. Note: This document contains side effect information about sibutramine. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Studies have indicated that Meridia along with a reduced calorie diet and an exercise routine can supposedly reduce weight by 5 to 10% the first year. Ernest D, Gershenzon A, Corallo CE, Nagappan R "Sibutramine-Associated QT Interval Prolongation and Cardiac Arrest (October)." Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Digestive System : diarrhea, flatulence, gastroenteritis, tooth disorder. impaired, confusion, depression aggravated, Gilles de la Tourette's syndrome, Includes 274 patient ratings with average score of 3.9, comments, side effects, dosage, sex, age, time taken. MERIDIA works in a different manner than other prescription weight management medications. of normal) occurred in 0% (alkaline phosphatase) to 0.6% (ALT) of the sibutramine The following additional adverse events were reported in ≥ 1% of all patients Our Meridia Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. See additional information. treated patients and in none of the placebo-treated patients. Meridia (sibutramine)." Urogenital System: abnormal ejaculation, hematuria, impotence, increased urinary frequency, micturition Rare side effects of Meridia occur in less than 2 percent of people taking the drug. Thickens mucus in the cervix to stop sperm from reaching or fertilizing an egg 2. MERIDIA should be given with caution to those patients with a history of hypertension, and should not be given to patients with uncontrolled or poorly controlled hypertension. If you or a loved one have taken Meridia and experienced any severe side effects or suffered injury, you should contact a doctor for proper medical attention. In 2009 a major study found that patients with a history of cardiovascular disease who took the medication had an elevated risk of heart attacks and strokes.… insomnia, constipation and headache. Tell your doctor if you are pregnant or plan to become pregnant while using Meridia; it is unknown if it will harm a fetus. If experienced, these tend to have a Less Severe expression. in ≥ 1% of sibutramine treated patients and more frequently than in the placebo If any of these events should occur during treatment with sibutramine (the active ingredient contained in Meridia) discontinuation should be considered. follow such patients closely, observing them for signs of misuse or abuse (e.g., Binkley K, Knowles SR "Sibutramine and Panic Attacks." SIDE EFFECTS In placebo-controlled studies, 9% of patients treated with sibutramine (n = 2068) and 7% of patients treated with placebo (n = 884) withdrew for adverse events. phentermine, liraglutide, amphetamine, methamphetamine, Saxenda, Alli. In these studies, the side effects that occur in a group of people taking the drug are documented and then compared to the side effects that occur in another group of people not taking the medicine. Sibutramine may have an effect on platelet function As with any drug, there are side effects associated with Meridia®. Rosenbohm A, Bux CJ, Connemann BJ "Psychosis with sibutramine." Meridia, an appetite suppressant, is being pulled off the market in Canada and the U.S., because of worries about the drug's links to side effects such as heart attacks and strokes. To prevent pregnancy, Mirena: 1. Meridia is an oral prescription medication to fight out obesity effectually. Tell your doctor all medications and supplements you use. Read the entire FDA prescribing information for Meridia (Sibutramine Hydrochloride Monohydrate). Pill Identifier Tool Quick, Easy, Pill Identification, Drug Interaction Tool Check Potential Drug Interactions, Pharmacy Locater Tool Including 24 Hour, Pharmacies. Knoll Pharmaceutical Company, Whippany, NJ. Meridia Side Effects warmth, redness, or tingly feeling under your skin. Hemic and Lymphatic System: anemia, leukopenia, lymphadenopathy, petechiae, thrombocytopenia. [Ref], Metabolic side effects have included thirst (1.7%) and generalized edema (1.2%). Copyright © 2018 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. Br J Dermatol 149 (2003): 215-6. Body as a Whole: anaphylactic shock, anaphylactoid reaction, chest pressure, chest tightness, Meridia (sibutramine) was withdrawn from the U.S. market due to the risk of serious cardiovascular events. Reported Meridia side effects include an increased risk of heart attack and stroke, uneven heartbeat and shortness of breath. If you believe you have been injured by Meridia side effects you should speak with a good products liability attorney who is experienced in working with victims of unsafe drugs. 2068) and 7% of patients treated with placebo (n = 884) withdrew for adverse the drug. Musculoskeletal System: arthrosis, bursitis. I have been on Meridia for two weeks, and have lost 5.2 pounds. provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Metabolic and Nutritional: peripheral edema. “When I took Slimex, I noticed my heart rate was a little high…” stated a customer. You may report them to the FDA. In placebo-controlled studies, the most common events were dry mouth, anorexia, Psychiatric side effects including cases of depression, psychosis, mania, suicidal ideation and suicide have been reported. It is used to treat very overweight (obese) patients who have not been able to lose weight using a low calorie diet and exercise. What does the FDA say about Meridia? Special Senses: abnormal vision, blurred vision , dry eye, eye pain, increased intraocular facial edema, limb pain, sudden unexplained death. Meridia side effects. during treatment with sibutramine, they may have no causal relationship with However, recent events have cast substantial shadows on both the effectiveness of Meridia, and more significantly, on the safety of Meridia. Meridia (sibutramine hydrochloride or sibutramine hydrochloride monohydrate) assists with weight-loss by altering neurotransmitters within the brain and is used along with a low-calorie diet to help people with obesity lose weight. Goh BK, Ng PP, Giam YC "Severe bullous drug eruption due to sibutramine (Reductil(R))." to angioedema and anaphylaxis have been reported (see CONTRAINDICATIONS and This drug is no longer offered in many countries including but not limited to the US, EU and India. I couldn’t sleep,” commented a user. show a clear dose-response relationship. Your next step should be to consult with an experienced attorney , who can discuss your options and help you protect your legal rights to compensation for injuries suffered by using Meridia. Meridia (Sibutramine Hydrochloride Monohydrate). These side effects must be kept in mind before consuming Meridia. Abnormal liver function tests, including increases in AST, ALT, GGT, LDH, alkaline events. studies. Am Heart J 142 (2001): 489-97, 7. obese patients in placebo-controlled trials compared with 0.8% of placebo patients. and Nutritional hyperglycemia, hypoglycemia. Mechanism of Action. Obese Patients in Placebo-Controlled Studies. Ultimately, Meridia is a prescription medication. Consumer ratings and reviews for MERIDIA. torsade de pointes, vascular headache, ventricular tachycardia, ventricular J Clin Psychopharmacol 27 (2007): 315-7, 8. home Convulsions were reported as an adverse event in three of 2068 (0.1%) sibutramine You may report side effects to FDA at 1-800-FDA-1088. These are not all the side effects of MERIDIA (sibutramine hydrochloride monohydrate) . function normalized. The study showed that there was only a small difference in weight loss among patients taking Meridia and those receiving the placebo. Meridia Capsule Side Effects by Likelihood and Severity COMMON side effects. What are some Meridia side effects? [Ref], Nervous system side effects have included dry mouth (17.2%), insomnia (10.7%), dizziness (7.0%), nervousness (5.2%), anxiety (4.5%), depression (4.3%), paresthesia (2.0%), somnolence (1.7%), CNS stimulation (1.5%), emotional lability (1.3%), amnesia, abnormal dreams, abnormal gait, amnesia, anger, cerebrovascular accident, impaired concentration, confusion, aggravated depression, Gilles de la Tourette's syndrome, hypesthesia, decreased libido, increased libido, mood changes, nightmares, short term memory loss, speech disorder, transient ischemic attack, tremor, twitch, and vertigo. Meridia users who suffered cardiovascular side effects of the drug may be entitled to collect financial compensation for medical bills, lost wages and other damages. Side Effects. drugs a-z list Cardiovascular System: angina pectoris, atrial fibrillation, congestive heart failure, heart arrest, I would like to lose 20 more pounds, but am a little concerned as I’ve started getting regular headaches for about 3-4 days now. And, as such, the company manufacturers offer a list of the possible side effects for the drugs. “The side effects weren’t worth it. Dujovne CA, Zavoral JH, Rowe E, Mendel CM "Effects of sibutramine on body weight and serum lipids: a double-blind, randomized, placebo-controlled study in 322 overweight and obese patients with dyslipidemia." What’s inside of it and are there side effects?-Sibutramine: The only active ingredient in Meridia, this drug has been pulled from most markets and is only available on websites that offer illegal substances such as steroids and prescription drugs. If One case of exacerbation of panic attacks has also been reported. Meridia may interact with other medicines that make you sleepy (such as cold or allergy medicines, sedatives, narcotics, sleeping pills, muscle relaxers, and medicines for seizures, depression, or anxiety), decongestants, cough medicines, other diet pills, lithium, L-tryptophan, ketoconazole, antibiotics, antidepressants, ergot medicines, or migraine headache medicines. Medicines and their possible side effects can affect individual people in different ways. extrasystoles, ventricular fibrillation. Common side effects. It has been associated with increased cardiovascular events and strokes and has been withdrawn from the market in several countries and regions including Australia, Canada, China, the European Union, Hong Kong, India, Mexico, New Zeal BMJ 329 (2004): 1316, 3. Such persistent side effects must be reported to the doctor. Respiratory System: epistaxis, nasal congestion, respiratory disorder, yawn. Nervous System: agitation, leg cramps, hypertonia, thinking abnormal. Skin and Appendages Am J Psychiatry 159 (2002): 1793-1794. ≥ 2 mg/dL; ALT, AST, GGT, LDH, or alkaline phosphatase ≥ 3 × upper limit phosphatase and bilirubin, were reported as adverse events in 1.6% of sibutramine-treated One case of exacerbation of panic attacks has also been reported. Digestive System: cholecystitis, cholelithiasis, duodenal ulcer, eructation, gastrointestinal hemorrhage, increased salivation, intestinal obstruction, mouth ulcer, stomach Ann Pharmacother (2008): 5. Endocrine System: goiter, hyperthyroidism, hypothyroidism. Meridia exerts its action by making you feel satisfied with the ingesting less food.. Harrison-Woolrych M, Clark DW, Hill GR, Rees MI, Skinner JR "QT interval prolongation associated with sibutramine treatment." Some side effects might be mild and go away after a couple of hours and other side effects might linger on for days. The FDA requested a Meridia recall after reviewing a study which showed an increased risk of stroke, heart attack and death among patients taking the prescription weight loss drug. General side effects, unrelated to a specific organ system, have included headaches (30.3%), back pain (8.2%), flu syndrome (8.2%), accidental injury (5.9%), asthenia (5.9%), abdominal pain (4.5%), chest pain (1.8%), and neck pain (1.6%). Acute interstitial nephritis (confirmed by biopsy) was reported in one obese Meridia® is not intended to be used alone; it should be prescribed in combination with diet and exercise. listed below). are listed below. We comply with the HONcode standard for trustworthy health information -. [Ref], Hematologic side effects including significant improvements in serum triglyceride and HDL-C levels have been reported. had potentially predisposing factors (one had a prior history of epilepsy; one Br J Clin Pharmacol 61 (2006): 464-9, 6. reported rarely in patients on sibutramine treatment. [Ref], Hypersensitivity side effects have included reactions ranging from mild skin eruptions and urticaria to angioedema and anaphylaxis.[Ref]. Clark DW, Harrison-Woolrych M "Sibutramine may be associated with memory impairment." A case of severe bullous drug eruption due to sibutramine (the active ingredient contained in Meridia) has also been reported. You may report side effects to Health Canada at 1-866-234-2345. rolled premarketing obesity studies. Thins the lining of the uterus and partially suppresses ovulationMirena prevents pregnancy for up to five years after insertion. Read the entire patient information overview for Meridia (Sibutramine Hydrochloride Monohydrate). Adverse events in these studies occurring Two of the three patients with seizures The adverse side effects that are being linked to the use of Meridia are serious and life threatening. Meridia Side Effects What Went Wrong Eventually, earlier in this decade, reports of Meridia side effects began to surface. This is the only side effect I’ve had – I love that Meridia has all but diminished my appetite. Meridia Side Effects. any of these events should occur during treatment with sibutramine, discontinuation Available for Android and iOS devices. Nervous System: abnormal dreams, abnormal gait, amnesia, anger, cerebrovascular accident, concentration tended to be sporadic, often diminished with continued treatment, and did not [Ref], Cardiovascular side effects have included tachycardia (2.6%), vasodilation (2.4%), migraine (2.4%), hypertension/increased blood pressure (2.1%), and palpitation (2.0%), arrhythmias, myocardial infarction, and cardiac arrest. PATIENT INFORMATION, and other reports of allergic reactions If any of these events should occur during treatment with sibutramine (the active ingredient contained in Meridia) discontinuation should be considered. Obesity itself, concurrent disease states/risk factors, or weight Consult your doctor before breastfeeding. A Stuffy And Runny Nose; Anxious Feelings; difficulty, urinary retention. These side effects were seen as especially dangerous for those who were using Meridia because of their obesity, and these Meridia side effects included: Primary Pulmonary Hypertension (PPH) [Ref], The manufacturer has reported that in placebo-controlled obesity studies, sibutramine 5 to 20 mg once a day has been associated with mean increases in systolic and diastolic blood pressure of approximately 1 to 3 mm Hg relative to placebo, and mean increases in pulse rate of approximately 4 to 5 beats per minute. heart rate decreased, myocardial infarction, supraventricular tachycardia, syncope, Cases of depression, psychosis, mania, suicidal ideation and suicide have been vertigo. © Meridia Patient Information is supplied by Cerner Multum, Inc. and Meridia Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights. Causal relationships have not been proven. [Ref], Musculoskeletal aches and pains associated with the use of this drug have included arthralgia (5.9%), myalgia (1.9%), tenosynovitis (1.2%), and joint disorder (1.1%). had a subsequent diagnosis of brain tumor). See additional information. Some of the dosage forms listed on this page may not apply to the brand name Meridia. Subscribe to newsletters for the latest medication news, new drug approvals, alerts and updates. 1. group are shown in the following table. The side effects from days 4-6 included massive fluid retention and increased blood pressure/pulse. Allergic hypersensitivity reactions ranging from mild skin eruptions and urticaria treated patients and in none of 884 placebo-treated patients in placebo-cont Metabolic due to its effect on serotonin uptake. Call your doctor for medical advice about side effects. Call your doctor for medical advice about side effects. 4. It is unknown if Meridia passes into breast milk or if it could harm a nursing baby. [Ref], Gastrointestinal side effects have included anorexia (13.0%), constipation (11.5%), increased appetite (8.7%), nausea (5.9%), dyspepsia (5.0%), gastritis (1.7%), vomiting (1.5%), and rectal disorder (1.2%).
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